At first sight, this idea seems to fit with the variety of endocrine, ectodermal, and lymphoid autoimmune diseases that present in patients with AIRE mutations and comprise the Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) or autoimmune polyendocrine syndrome type I (APS-I) syndrome (4–6). This evidence concerns the gene AIRE and autoimmune polyendocrine syndrome type 1.