Aire−/−/Cbl-b−/− mice showed additional lymphocytic infiltrates in submandibular salivary glands and stomach (39), while Aire-deficiency on the NOD background was accompanied by severe pulmonitis and infiltrates in liver, salivary gland, prostate, ovary, stomach, and thyroid (53, 82). This evidence concerns the gene AIRE and hyperinsulinemic hypoglycemia, familial, 4.