Hamada et al. (2012) have reported that pancreatic cancer cells in co-culture with PSCs show increased expression of stem cell related genes such as nestin, ABCGZ, and LIN28, supporting the possibility that a PSC-facilitated cancer stem cell niche may be one of the factors responsible for recurrence of pancreatic cancer. The gene discussed is LIN28A; the disease is familial pancreatic carcinoma.