ALB and familial pancreatic carcinoma: However, with regard to the anti-cancer effects, it is postulated that the albumin in nab-paclitaxel is bound by secreted protein acidic and rich in cysteine (SPARC), an albumin binding glycoprotein that is overexpressed in pancreatic cancer stroma (Neuzillet et al., 2013), leading to accumulation of nab-paclitaxel near tumor cells (Yardley, 2013).