RanBP9 regulates Aβ peptide production in several cell lines and primary neuronal cultures and exerts its actions by forming protein complexes with APP, LRP, and BACE1, leading to the increased proteolytic processing of APP, secretion of sAPPβ, and generation of Aβ, which is present in excessive amounts in the brains of AD patients. This evidence concerns the gene BACE1 and Alzheimer disease.