HCRT and addictive behaviour: Recent excellent reviews summaries the evidence collected in more than hundred articles indicting that the hypocretin/orexin system in the lateral hypothalamus (Harris et al., 2005) is involved in the behavioral addiction-like dysregulations associated with exposure to cocaine, amphetamine, morphine, heroin, nicotine, ethanol and cannabinoids in rodents (Espana et al., 2011; Mahler et al., 2012; Boutrel et al., 2013; Flores et al., 2013), as well as in the excessive intake of palatable food associated with binge eating (Tsujino and Sakurai, 2013).