As mentioned above, neurons that produce hypocretin/oirexin are located in the perifornical region (Peyron et al., 1998) and project to the majority of the limbic brain structures involved in the fear, stress and anxiety circuit (Shin and Liberzon, 2009), suggesting a possible role of hypocretin/orexin in controlling not only wakefulness and arousal, but also fear, anxiety, and stress responses (Johnson et al., 2012a; Sears et al., 2013). Here, HCRT is linked to Anxiety.