ANXA2 and breast cancer: Furthermore, ANXA1 or ANXA2 mRNA or protein levels are altered in various human diseases, for example, cystic fibrosis [20, 21], hepatocellular carcinoma [22, 23], prostate carcinoma [24–26], pancreatic cancer [27, 28], breast cancer [29–31], and renal cell carcinoma [32, 33].