In addition, ANXA1 has been described as playing a homeostatic role in cells of the innate immune system [15, 58] and to act as a protective and anti-inflammatory protein in models of rheumatoid arthritis and myocardial infarct [15, 59, 60] by direct inhibition of phospholipase A2 [14]. Here, PLA2G4A is linked to rheumatoid arthritis.