Several reports have demonstrated that cytoplasmic ANXA1 can be induced to translocate into the nucleus by treatment with specific stimuli, such as EGF in the case of alveolar basal epithelial cells [50] and PMA in the case of human embryonic kidney cells [51], suggesting that ANXA1 nuclear translocation is involved in the regulation of cellular proliferation and may be directly involved in tumor invasion [52]. Here, EGF is linked to neoplasm.