As shown in Figure 6, although ISH showed that very little ANXA1 mRNA was expressed in the tubules or glomeruli in the normal controls (bottom line, left panels) and patients with MCD (top line, left panels), most biopsy tissues from other types of glomerular disorders were found to have high levels of ANXA1 mRNA in the glomeruli examined. This evidence concerns the gene ANXA1 and glomerular disorder.