TBX1 and germ cell tumor: Though a focal, weak, immunoreactivity for brachyury was occasionally noted in germ cell tumors, both seminoma and unspecified subtypes [8, 12], no staining for this protein was found in a more extensive study of 111 germ cell tumors, including different subtypes [11], and we also failed to find any brachyury immunohistochemical expression in a small cohort of 10 seminomas (unpublished data) (Figure 1(c)).