Indeed, chordoma was originally described as one of the unique “triple positive” EMA/S100 protein/keratins neoplasia in bone and soft tissue pathology [23] and diffuse immunostaining for wide spectrum cytokeratins, cytokeratin-8, cytokeratin-19, and cytokeratin-18 was demonstrated in this tumour [24]. Here, KRT18 is linked to keratinization.