STK11 and Peutz-Jeghers syndrome: These new findings include rare germline mutations in other high penetrant genes; the most important between them include TP53 mutations in Li-Fraumeni syndrome, STK11 (serine/threonine kinase 11) mutations in Peutz-Jeghers syndrome, and PTEN (phosphatase and tensin homolog on chromosome ten) mutations in Cowden syndrome.