Recent studies have identified miR-210 in a microarray analysis as the predominant miRNA induced by hypoxia in cancer cell lines, such as breast, head and neck, lung, colon, and renal cancer cell lines [27], and demonstrated the direct regulatory role of hypoxia-inducible factor-1 alpha (HIF-1a) in its transcription [12, 16, 21]. This evidence concerns the gene HIF1A and cancer.