Different isoforms of SNCA resulting from alternative mRNA splicing were investigated in PD, DLB, and MSA and isoform SNCA 98 was found to be up-regulated in the frontal cortex of MSA, while there was no significant difference in the level of SNCA 126 (Beyer et al. 2008). The gene discussed is SNCA; the disease is Lewy body dementia.