Therefore, various growth factors and chemokines secreted by TAMs, like epidermal growth factor (EGF), transforming growth factor-β (TGF-β), interleukin-8 (IL-8) and tumour necrosis factor-α (TNF-α) contribute to the migration of tumour cells towards vessels and provide proliferative and anti-apoptotic signals to these cells [16,17]. The gene discussed is EGF; the disease is neoplasm.