An association of TRAF1 (TNF receptor-associated factor 1) and ARG1 (Arginase 1) expression in whole blood and an association with TLR4 (Toll-like receptor 4) expression in CD4+T cells were observed.90 They also reported that the serological status of the RA patient has no predictive value for rituximab outcome. This evidence concerns the gene CD4 and rheumatoid arthritis.