Sensitizing cells to TRAIL by reducing FLIPL levels is a widely recognized mechanism (Geserick et al., 2008; Zhang et al., 2010) and was shown to be involved in tumor regression (Ganapathy et al., 2009) Intriguingly, increased FLIPL levels were observed during transformation and melanoma formation as a mechanism of developing intrinsic resistance to apoptosis (Rippo et al., 2004). This evidence concerns the gene TNFSF10 and neoplasm.