Wolfram syndrome, also known as DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness), is an autosomal recessive disorder [1] caused by more than 100 mutations in the WFS1 gene, which was identified by positional cloning in 1998 [2–4]. This evidence concerns the gene WFS1 and Leber hereditary optic neuropathy.