Further studies into metastatic mechanisms showed that SDF-1/CXCR-4 could modulate proliferation and progression of pancreatic cancer cells through CXCR-4-dependent activation of signal pathways, such as MAPK/ERK1/2, PI3K/Akt, FAK, Src, and STAT, which plays a core role in its devastating behavior [75–77]. Here, CXCR4 is linked to familial pancreatic carcinoma.