Similarly, PEGylated human recombinant PH20 hyaluronidase (PEGPH20), which can enzymatically diminish hyaluronan (HA) and induce remodeling of blood vessels inside tumor, rise the delivery of gemcitabine, inhibiting tumor growth and prolonging survival in a genetically engineered mouse model of PDAC [130]. Here, SPAM1 is linked to neoplasm.