SPRY2 and familial pancreatic carcinoma: Kim et al. found that the expressions of genes such as SCA1, TNFRSF5, and SIX1 were significantly upregulated in pancreatic cancer patients with lymph node metastasis, while those of CAMKK2, GADD45A, ATF3, SLIT2, SPRY2, CTNNB1, CDH19, and TLN2 were obviously downregulated, and further presumed that they might contribute to the process of lymph node metastasis by involvement of apoptosis, cell cycle, cell growth, cell adhesion, and motility [26].