CCL21 and neoplasm: Furthermore, EGFR-3 expressed on lymphatic endothelial cells which can bind with VEGF-C/D secreted by both pancreatic cancer cells and tumor-associated macrophages (TAMs) results in tumor lymphangiogenesis and chemoattraction of tumor cells toward LECs [84, 90], the latter is also propelled simultaneously by the axis of CCR7/CCL21 via a similar mechanism that dendritic cells homing to lymphatic vessels [81, 96].