Apart from this, growing evidence indicated that proinflammatory cytokines including interleukin-1 (IL-1), Il-6, IL-11, receptor activator of NF-κB ligand (RANKL, also known as TNFSF11), and TNFα play a pivotal role in pancreatic cancer initiation and progression [109]. This evidence concerns the gene TNFSF11 and familial pancreatic carcinoma.