CXCL12 and neoplasm: Additionally, taking the distinct distribution of SDF-1/CXCR-4 in the main sites of pancreatic cancer metastasis [9, 16] and significant depressive effect on tumor migration interfered by CXCR-4 antagonist and such as shRNA, AMD3100, and TN14003 [31, 79] into consideration, the signal axis of SDF-1/CXCR-4 is crucial for the lymphatic metastasis of pancreatic cancer.