EGFR-3 expressed on lymphatic endothelial cells which can bind with VEGF-C/D secreted by both pancreatic cancer cells and tumor-associated macrophages (TAMs) results in tumor lymphangiogenesis and chemoattraction of tumor cells toward lymphatic endothelial cells (LECs) [80, 84, 90]. Here, VEGFC is linked to familial pancreatic carcinoma.