VEGFC and metastatic malignant neoplasm in the lymph nodes: Kurahara and his coworkers (colleagues) [84] found that high expression of VEGF-C or VEGF-D in the marginal of primary tumor had a significantly higher incidence of lymph node metastasis, whereas the neoplastic lymphatic inside the tumor made no contribution to lymph node metastasis due to its nonfunctional lumen, which is coincident with other reports in PDAC [14, 92, 99].