Further research showed that integrin α4β1 (also known as VLA-4) expressed in VEGFR1+ cells, when binding with its ligand fibronectin, may facilitate migration of HPCs and circulating inflammatory cells to metastatic niche, and activate VEGFR1+ BMDCs to release various proteinases including MMP-9 in premetastatic niche to destruct basement membranes of ECM to create a conducive microenvironment for engraftment of tumor cells. Here, FN1 is linked to neoplasm.