KRAS and cancer: Upregulation of alpha-SMA and palladin in fibroblasts induced by the cancer cells containing activated KRAS, the de novo CAFs can promote pancreatic tumorigenesis and progression through their morphologically forming invadopodia-like cellular protrusions which could secrete invadopodia proteins and proteolytic enzymes such as ADAM22, aminopeptidases, and cathepsins D and B used for decomposing the ECM and create an optimum premetastatic niche.