BAX and Miyoshi myopathy: In our present work, we have examined the effect of ebselen on multiple myeloma (MM) cell lines; we found that ebselen can enhance the production of endogenous ROS, which further induce mitochondrial membrane potential lost and mitochondrial cytochrome C release by translocation of Bax protein into the mitochondria, ultimately triggered the mitochondrial-mediated apoptotic pathway.