HSPD1 and Behcet disease: Although Kaneko et al. [49] and others [5–7] have already reviewed on the role of infectious agents in BD pathogenesis, we also dare to propose the hypothesis that after Bes-1 gene taken in the cytoplasm of APCs through the TLRs in the oral cavity, the APCs, which are expressing the streptococcal antigen, produce HSP-65/60, as demonstrated by Deniz et al. [58].