If these APCs are curried in the blood flow to the impaired and/or MICA expressed endothelium of the vessels in correlation with HSP-65/60, VEGF, adhesion molecules, and so forth, BD lesions might be induced by the “vascular reaction” and/or “lymphocytic vasculitis” as the immunological reaction by the APCs expressing S. sanguinis antigen. The gene discussed is HSPD1; the disease is Behcet disease.