In the treatment by antibiotics for the involvement of oral S. sanguinis, especially minocycline, which not only reduces the growth of streptococci but also suppresses IL-1β and IL-6 production from T cells inflamed, was clinically effective for aphthous ulceration, acne-like eruption and EN-like lesion in BD patients [9]. The gene discussed is IL6; the disease is Behcet disease.