OTUB1 and Plasmodium vivax malaria: Several of the immune genes that have been identified in regions under selection are under the selective pressure of known pathogens, such as the Duffy blood group atypical chemokine receptor (DARC) gene to Plasmodium vivax malaria [79], ras homolog family member A (RHOA), and OTU domain ubiquitin aldehyde binding 1 (OTUB1) genes to Yersinia pestis (plague) [80], or the tyrosylprotein sulfotransferase 1 (TPST1) gene to HIV [81].