It is generally accepted that caspase-8 may suppress necroptosis through cleavage and consequent inhibition of RIP1 and RIP3 [17, 19]; it is therefore possible to hypothesize that in physiological conditions caspase-8 is active in suppressing T cells necroptosis, whereas, in pathological conditions, such as viral infection, caspase-8 may be inactivated and consequently T cells may die via necroptosis [49]. Here, CASP8 is linked to viral infectious disease.