Analysing insulin sensitivity and antioxidant enzyme activity in patients with or without T2DM and various stroke subtypes, A. Jotic et al. in their paper titled “Type 2 diabetic patients with ischemic stroke: decreased insulin sensitivity and decreases in antioxidant enzyme activity are related to different stroke subtypes” show that reduced insulin sensitivity and glutathione reductase are associated with atherothrombotic and lacunar stroke in T2DM. This evidence concerns the gene INS and ischemic stroke.