Considering that high serum levels of CRP have been associated with leukoaraiosis and that several studies indicated that leukoaraiosis is associated with cognitive impairment, the aim of this study was to examine how much is the effect of CRP on cognition and if it was mediated by leukoaraiosis or not in a sample of coronary patients. The gene discussed is CRP; the disease is Abnormal cerebral white matter morphology.