Assessing Pearson's partial correlation coefficients, controlling for age, sex, and educational level, we found negative correlation between CRP and MMSE (r: −0.268; P: 0.002) and positive correlation between CRP and presence of leukoaraiosis lesions on CT (r: 0.209; P: 0.017). This evidence concerns the gene CRP and Abnormal cerebral white matter morphology.