With these results we found that the CRP levels can explain 7.18% (P: 0.002) of the variance of ΔMMSE, and adjusting for leukoaraiosis this variance little changed (5.98%; P: 0.005), showing that little CRP influence on cognition was mediated by leukoaraiosis, as evaluated by CT scan. Here, CRP is linked to Abnormal cerebral white matter morphology.