More specifically, zinc deficiency in mice was shown to block the development of bone-marrow pre-B and immature B-cells, resulting in reduced B lymphocytes in the spleen; pre-natal zinc deficiency in monkeys and mice reduced lymphocyte numbers and IgG concentrations and produced long-term suppression of IgM, IgA and IgG. The gene discussed is CD40LG; the disease is Zinc deficiency.