Active angiogenesis during HCC development and progression is likely due to the rich expression of pro-angiogenic factors such as VEGF [3] and its receptors (VEGFR-1, -2 and -3), all of which have been observed in ample abundance in HCC cell lines and the serum of HCC patients [3], [17]. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.