Many aberrantly regulated signaling pathways, such as PI3K/AKT/mTOR pathway, RAF/MEK/ERK pathway, WNT/β-Catenin pathway, and VEGF/VEGFR pathway, have been reported in HCC [2]–[4] and these molecular pathways may constitute ideal targets for HCC therapy and prevention. This evidence concerns the gene AKT1 and hepatocellular carcinoma.