Alcendor et al., [15] found that overexpression of SIRT1 by 2.5 to 7.5 fold decreased age-related cardiac hyperthropy, apoptosis, cardiac dysfunction, and expression of senescence markers while overexpression of SIRT1 by 12.5 fold resulted in oxidative stress, apoptosis, and increased cardiac hyperyhrophy. Here, SIRT1 is linked to age.