When we analyzed the prevalence of these autoreactive IgE’s in SLE subjects with hypocomplementemia, it was higher in the French cohort (90%) than in the US cohort (72%) with dsDNA-specific IgE being found in 60% of the US and 80% of the French SLE subjects with hypocomplementemia (Figure S2B in File S1). Here, IGHE is linked to systemic lupus erythematosus.