As shown in Figure 4A, high levels of IgE autoantibodies to APEX nuclease 1 (APEX), N-methylpurine-DNA glycosylase (MPG), and CAP-GLY domain containing linker protein family member 4 (CLIP4) were found in some SLE subjects but were minimally detected in healthy controls. This evidence concerns the gene APEX1 and systemic lupus erythematosus.