IGHE and systemic lupus erythematosus: Analysis of the predictive value of autoreactive IgE’s or IgG’s for active disease in SLE subjects demonstrated that anti-dsDNA IgE and anti-dsDNA IgG were significant in predicting SLE subjects with active disease (Table 3, AUC = 0.769, Youden’s J = 0.37), compared to the individual analysis of each of the predictors (dsDNA-IgE: AUC = 0.72, Youden’s J = 0.36; dsDNA-IgG: AUC = 0.737, Youden’s J = 0.347).