IGHE and systemic lupus erythematosus: While more than 50% of SLE subjects had autoreactive IgE to one or more of the four common SLE auto-antigens, the prevalence of these IgE’s in active SLE subjects (SLEDAI ≥4) was 73.7% and 74.1% for the French and US subjects, respectively, with dsDNA specific-IgE being the most prevalent (US = 62.8%, French = 63.2%) (Figure S2A in File S1).