Normally, IgE functions to protect against various parasitic infections [8], but it is best known to mediate type I hypersensitivity since it binds the high affinity receptor for IgE (FcεRI) on mast cells and basophils (key cells in allergy) and upon allergen recognition causes the activation of these cells and the release of allergic mediators [9]. The gene discussed is IGHE; the disease is Allergy.