SPHK1 and cancer: The results demonstrated that significant differences in SK1 positivity/high expression rates were found between cancer and non-cancer tissues, cancer and adjacent non-cancer tissues, cancer and benign tissues, and adjacent non-cancer and benign tissues (all P < 0.0001); the respective OR (95% CI) were 11.86 (6.37–22.08), 6.66 (3.47–12.79), 11.94 (6.65–21.46), and 2.68 (1.70–4.20).