Normal human keratinocytes were found to constitutively bear the IL-17 receptor (IL-17R) and they are able to produce several IL-17-induced inflammatory and immune-related mediators implicated in psoriasis pathogenesis (e.g. IL-8, CCL20, S100A12, CXCL1, and CXCL2). This evidence concerns the gene S100A12 and psoriasis.