Though further studies may be needed to provide the functional and histological proof of the protective effect of antioxidants on age related hearing loss, the strong correlations between both Txnrd1 or Gpx6 expression on one hand and ABR thresholds and DPOAE amplitudes on the other hand, point to direct relations of the expression of these genes in the cochlea with age and hearing loss. The gene discussed is GPX6; the disease is hearing loss disorder.