Since single-nucleotide polymorphisms (SNPs) are the most common forms of human genetic variation and may affect cancer risk by influencing individual susceptibility [15], SNPs in DR4, FAS and FASL gene that impair the apoptotic signals represent the plausible and promising etiologic pathways modifying the GBC penetrance and merit to be tested as risk factors of gallbladder cancer susceptibility. The gene discussed is TNFRSF10A; the disease is cancer.