Our results indicate that maternal micronutrient deficiency (folic acid and vitamin B12) resulted in the following changes in the pup liver 1) lower expression of PPARα, PPARγ genes 2) No change in the expression of SREBP-1c, LXRα, RXRα expression in the pup liver and 3) Increased levels of pup liver global DNA methylation. The gene discussed is RXRA; the disease is hyperinsulinemic hypoglycemia, familial, 4.