Considerable proteins, such as YWHAZ, S100-A11, glutathione S-transferase, alpha-enolase, flavin reductase, fascin, and carbonic anhydrase, have been reported to be associated with laryngeal carcinoma in previous proteomics studies but without clinical validation and in-depth functional research [17], [18]. This evidence concerns the gene S100A11 and laryngeal carcinoma.