However, in our present study, four of the altered expressed proteins with different subcellular localization, such as PFN1: extracellular, NCL: nucleolus, nucleus and cytoplasm, CNDP2: cytoplasm, and OGN: extracellular, have been observed to be differentially expressed in cancers from other origins but not previously in laryngeal carcinoma [21]–[24]. This evidence concerns the gene PFN1 and cancer.