Moreover, we have recently shown in different murine infection models that Toll-like-receptor (TLR)-4 dependent signalling of C. jejuni lipooligosaccharide is a key factor in C. jejuni induced immunopathology as indicated by ameliorated clinical and intestinal immunopathology in C. jejuni infected gnotobiotic TLR-4 deficient as well as IL-10 deficient mice lacking TLR-4 [18], [21], [30]. The gene discussed is IL10; the disease is infection.