Since ERK-p is in turn involved in the activation of SREBP by phosphorylation [37], [52], [53] these observations reflect a contradictory signal triggered in PrAT of animals exposed to diet-induced obesity for a long time; i.e., suppression and activation of lipogenic gene expression simultaneously, with the ERK-p status being CB1 dependent. The gene discussed is CNR1; the disease is obesity disorder.