A large number of RNA-binding proteins have prion-like domains (e.g. HNRNPA1, HNRNPAB, HNRNPA2B1, TDP-43 [78]), some of these, such as TDP-43, have been implicated as major disease proteins in neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration and as secondary features of diseases like Alzheimer’s disease and Parkinson’s disease [79]. This evidence concerns the gene TARDBP and early-onset autosomal dominant Alzheimer disease.