Assuming PS was externalized by apoptosis induction after treating with PEG-b-PCL micelles carrying PTX, CYP, and GSP in equally-sized ES-2-luc tumor spheroids, DiR molecules delivered by apoptosis-targeting PEG-b-PCL micelles were observed in tumor spheroids without PS saturation based on FLI of DiR, whereas 42±4% of DiR molecules delivered by the same micelles were detected in tumor spheroids under the condition of PS saturation, indicating decreased DiR accumulation by 2.4-fold in a competitive binding test. Here, PPIG is linked to neoplasm.