Confocal microscopic images of collected tissues demonstrated that a single IP injection of PEG-b-PCL micelles carrying PTX, CYP, and GSP at 30, 30, and 30 mg/kg, respectively, in ES-2-luc-bearing animals increased the level of apoptosis in tumor tissues over time, reaching to the peak apoptosis level on day 1 post drug treatment. The gene discussed is GNAS; the disease is neoplasm.