Moreover, a tumor priming strategy achieved by IP injection of PEG-b-PCL micelles carrying PTX, CYP, and GSP followed by an IV injection of methoxy-PEG-b-PCL micelles carrying DiR, was also insufficient to deliver DiR-incorporated methoxy-PEG-b-PCL micelles to metastatic tumor tissues in our ES-2-luc-bearing xenograft model (data not shown). This evidence concerns the gene GNAS and neoplasm.