Such NR2B hyper-activation was confirmed at different time-points after epilepsy onset (Figure 8E–F): the phospho-NR2B/total NR2B ratio was consistently and significantly increased in the hippocampus in early chronic and chronic epilepsy stages, and it increased progressively in the neocortex during epilepsy course (Figure 8F), suggesting that steady NR2B activation was a key point in the spontaneous seizure activity of epileptic MP rats. The gene discussed is GRIN2B; the disease is epilepsy.