To see whether the IFN-α1 produced in the cells without virus infection affects the cells through the autocrine or paracrine signaling regardless of low level production, the basal expression of several ISGs in HuS-E/2 cells cultured in the medium containing nAb targeting IFNα/β receptor (IFNAR) 2, one of the receptors for type I IFN, were investigated. The gene discussed is IFNA1; the disease is viral infectious disease.