Previous studies have reported an estimated carrier rate of 3.16–11.72% for α-thalassemia and 1.96–3.87% for β-thalassemia in some regions of Guangdong Province [9], [10]; however, these studies may not reveal the true prevalence of thalassemia in Guangdong province because of a limited sampling area and sample size. Here, PPIB is linked to thalassemia.