In addition, osteopontin is associated with the migration of vSMCs[84] and is considered an osteogenic molecule that would support vascular calcification in atherosclerosis.[85] Thus, the interactions of syndecan-1 with integrins αvβ3 and αvβ5 appear to be critical to its activity in suppressing the inflammatory and osteogenic state in vSMCs. Here, SPP1 is linked to atherosclerosis.