Immunohistochemical staining showed that STAT3, p-STAT3 and its downstream genes c-Myc, cyclinD1, survivin and VEGF could be detected in either cytoplasm or the nuclei of tumor tissues in NaCl control group but became apparently reduced in resveratrol-treated tumors (Figure 6; Table 2). The gene discussed is STAT3; the disease is neoplasm.