Whereas inhibition of various HDAC enzymes has been shown to cause myc repression in a range of human cancer cell lines [21], [55]–[57], which corresponds well with the data in the present study, specific nuclear induction of myc to mediate HDAC inhibitor-induced apoptosis in glioblastoma cell lines has also been demonstrated [58]. This evidence concerns the gene MYC and glioblastoma.