TGFB2 and thoracic aortic aneurysm: Following the identification of loss of function mutations in the Tgfb2 gene in humans with thoracic aortic aneurysm, however, the mouse model was revisited and Lindsay and colleagues showed that the haploinsufficient Tgfb2 mice (Tgfb2+/−) showed significant dilatation of the aortic annulus and root at the age of 8 months [24].