It has been previously described an altered homeostasis of human platelets in HD [25], [26] and an increased density of Adenosine A2a receptor, a protein G-coupled receptor implicated in the regulation of different biochemical processes including the release of NO, in both CNS of transgenic HD mice [13], [27] and blood platelets of patients [5], [6]. Here, ADORA2A is linked to Huntington disease.