As observed when LXA4 was administered on D−1, IL-1β, COX-2, VEGF, MRP4, TGF-β1, TGF-β2, CYP19a1, ERα, GREB1 and c-Myc expression were significantly attenuated whereas MMP-9 and TGF-β3 were upregulated in endometriotic lesions in established endometriosis (Figure 7Ba-l). Here, ESR1 is linked to endometriosis.