Current data suggests that the rs4779584polymorphism within the 15q13.3 chromosomal region is associated with an increased risk ofdeveloping colorectal cancer [8]–[16].Rs4779584 lies between the GREM1 and SCG5 genes.GREM1 encodes gremlin 1, which is a signaling molecule in the transforming growthfactor-β (TGF-β) pathway. The gene discussed is GREM1; the disease is colorectal cancer.