These mice develop a T-ALL-like disease with a disease latency of 35 weeks months [5], [12] In both reports, there was an extended latency prior to the development of malignant disease, suggesting that ectopic expression of TLX1, by itself, was insufficient to initiate malignancy and that additional mutations were required for premalignant cells to progress to full malignancy. Here, TLX1 is linked to acute lymphoblastic leukemia.