Consistent with gene expression patterns in human T-ALLs, these analyses revealed a statistically significant (p<0.05) reduction in the expression of Bcl11b and Pten in T-ALL arising in IgHμ-TLX1TgPrkdcScid/Scid mice relative to tumors isolated from PrkdcScid/Scid mice (Figure 6). This evidence concerns the gene PTEN and acute lymphoblastic leukemia.