These data are similar to our findings in regular NOD mice [4] and suggest that the lower susceptibility of Idd3/10/18 mice to develop type 1 diabetes following PDL1 blockade is probably not dependent on expansion of CD4 and CD8 T cells, rather that anti PDL1 treatment likely affects behavior of these cells which contributes to lowering susceptibility for developing disease. This evidence concerns the gene CD8A and type 1 diabetes mellitus.