The Idd5.3 strain had the highest cumulative incidence of type 1 diabetes following anti PDL1 treatment, with 90% of the mice developing disease by day 30 (P = 0.0140 Idd5 vs Idd5.3), followed by Idd5.2 with 80% cumulative incidence (P = 0.0194 Idd5 vs Idd5.2). Here, CD274 is linked to type 1 diabetes mellitus.