Our data show that PDL1 blockade is not enough to induce accelerated diabetes in the NOD Idd3/5 congenic mice strain that contains alleles for Il2, Ctla4, Slc11a1 and Acadl. The interaction between these alleles is able to protect the mice from diabetes induction by PDL1 blockade. This evidence concerns the gene SLC11A1 and diabetes mellitus.