Surprisingly, maspin did not demonstrate a dependence on TGFβ treatment or p53 expression in OVCA420 p53 shRNA or SKOV3 R273H mutant p53 cell lines (data not shown) compared to parent cells suggesting that additional pathways modify p53 and Smad regulation of maspin in ovarian cancer cells. The gene discussed is TGFB1; the disease is ovarian carcinoma.