On the other hand, knockdown of OCTN1 greatly decreased ERGO transport activity (Fig. 4C) and promoted the formation of neurospheres (Fig. 4D, E) with concomitant up-regulation of HO-1, xCT, and CyclinD1 (Fig. 5B) in NPC-model P19 cells. The gene discussed is SLC22A4; the disease is nasopharyngeal carcinoma.