This was consistent with MECOM being a known dynamic modulator of transcription that can either activate or repress genes, depending on the recruitment of coactivators or corepressors [46].Of the 13 genes regulated by Evi1 both in cardiac development and in SKOV3 ovarian carcinoma cells, 9 genes showed Evi1-mediated changes in expression level in a similar manner (Jun, Thbs1, Adam9, Hey1, Jag1, Nrp2, Rarg, Sox4, and Tgfbr2). This evidence concerns the gene HEY1 and ovarian carcinoma.