Glaucoma is a complex disease and numerous retina proteins have been demonstrated to be up-regulated during the pathogenesis of glaucoma, including TNF-α, TNF-R1, various protein kinases, glial cell activation, and proteolytic caspases [7], [20], [28]–[30], [41], [42]. The gene discussed is TNFRSF1A; the disease is glaucoma.